Learn what it does. 1. This is one of the most common reasons why caffeine doesn’t affect you anymore. There is also a general belief that caffeine makes people more anxious and hinders sleep. I can down two cups before bed and still sleep soundly, which I know shouldn't be the case. For instance, the effect caffeine has on level of stimulation may mitigate the reduction in metabolism. Though, now that others mention it, I do see a slight increase in my ability to focus when I ingest it. I drink milk most of the time. Studying how genes affect coffee consumption habits is nothing new. Caffeine can disrupt sleep and reduce blood flow to the brain in most people. Send thanks to the doctor. Or is supposed to unless you tell your body it doesn't. Thanks! Dr. Yash Khanna answered. I swallowed two 200mg caffeine pills yesterday and then downed a 175 mg caffeine pre workout yet I still don’t feel energized or affected at all. Anyway, that was a tangent. 1 thank. Why caffeine doesn’t leave everybody wired. "People who are caffeine sensitive may notice stomach upset when they drink caffeine … A 45-year-old member asked: Can there be an energy drink or something that doesn't rely on caffeine? However, it has a different effect on people with ADHD. According to the U.S. Food and Drug Administration, the average American consumes 300 milligrams of caffeine each day, and the Mayo Clinic says it is safe for adults to consume upward of 400 milligrams daily-- the equivalent of four cups of coffee.It is our most popular caffeine delivery mechanism by magnitudes, and provides quite a few health benefits as well. for some reason, coffee, energy drinks, ect, have never affected me even slightly. Norepinephren: These substances increase the effect of norepinephren an excitatory brain chemical. Caffeine can also affect sensitive people's GI tract, causing some rather unpleasant side effects. To be sure, coffee is safe. Call me crazy but I love it and prefer it over any other drink. Many sufferers find it has the opposite effect than it does in other people: instead of making them more active and stimulated, it actually has more of a “calm-down” effect, and encourages sleep. In the following picture, you can see what happens when you’ve built up a caffeine tolerance: If you decide to increase your daily coffee consumption just know that according to the FDA you shouldn’t go over 400 mg of caffeine per day . If anyone can tell me why or why they think why I would appreciate it. In … Also, there are two common liver enzymes in the population fur metabolism of caffeine. Caffeine is considered a drug which means it affects your mind. Why doesn't caffeine affect me? See most things that occur are because of your mind, if you notice that say you get a cut on your arm, it doesn't really hurt until you look at it. =) Caffeine is the most widely consumed stimulant in the world.That being said, it does not affect everyone in the same way. One is a 6 hour hand life, the other is a 3 hour half life. Now what caffeine does is tell your body that your not tired. 0. 56 years experience Family Medicine. I’ve never drank coffee or taken energy drinks, so I don’t understand why caffeine doesn’t affect my body. Just want to add that I have ADHD and caffeine does nothing to aid in my ability to stay awake. I am going to try a stimulant med soon, so far strattera doesn't seem to be enough anymore. So, I've never had a ton of caffeine to be able to build up a tolerance to it, but it still doesn't affect me in a way that wakes me up, it just helps relax my body. 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